Swelling Around the Eye (Romaña Sign)

One of the most recognizable early signs of Chagas infection is swelling around one eye, known medically as Romaña sign. This occurs when parasite-contaminated feces enter the eye after a bite near the face.
The eyelid may appear puffy, reddish, and inflamed, usually without much pain. While this sign does not appear in everyone, it is a strong indicator of early infection and requires immediate medical attention.
Flu-Like Symptoms That Seem Unrelated
Within a few weeks after being bitten, some people develop mild flu-like symptoms. These often include:
- Fever
- Fatigue or weakness
- Headaches
- Muscle or joint pain
- Loss of appetite
Because these symptoms resemble a common viral illness, they are frequently overlooked or misdiagnosed.
Swollen Lymph Nodes
Another early warning sign is swollen lymph nodes, particularly near the site of the bite. This swelling occurs as the immune system responds to the parasite. Lymph nodes in the neck, armpits, or groin may feel tender or enlarged.